The Flagellum Attachment Zone: ‘The Cellular Ruler’ of Trypanosome Morphology
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منابع مشابه
The Flagellum Attachment Zone: ‘The Cellular Ruler’ of Trypanosome Morphology
A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the flagellum to the cell body, mediated by the flagellum attachment zone (FAZ). The FAZ is a complex cytoskeletal structure that connects the flagellum skeleton through two membranes to the cytoskeleton. The FAZ acts as a 'cellular ruler' of morphology by regulating cell length and organelle position and is theref...
متن کاملThe trypanosome flagellum.
Introduction African Trypanosomes are flagellated protozoan parasites that cause sleeping sickness in humans and Nagana in cattle. During its life cycle, Trypanosoma brucei alternates between an insect vector (tsetse fly) and a mammalian host. Within each of these, the parasite proliferates and undergoes separate periods of differentiation in preparation for each new host/vector environment. Th...
متن کاملThe Structural Basis of Localizing Polo-Like Kinase to the Flagellum Attachment Zone in Trypanosoma brucei
The polo-like kinase in the deep branching eukaryote Trypanosoma brucei (TbPlk) has many unique features. Unlike all the other polo-like kinases known to associate with the nucleus and controlling both mitosis and cytokinesis, TbPlk localizes to the flagellum attachment zone (FAZ) and regulates only cytokinesis in T. brucei. TbPlk was, however, previously found capable of complementing all the ...
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ژورنال
عنوان ژورنال: Trends in Parasitology
سال: 2016
ISSN: 1471-4922
DOI: 10.1016/j.pt.2015.12.010